Symptoms reported vary between late versus early-onset cases of CMT4J. Adaptive equipment is typically needed prior to adulthood. Common signs and symptoms during this time include:

  • Overwhelming fatigue
  • Speech or eating challenges
  • Respiratory compromise or muscle weakness leading to respiratory infections
  • Rapidly progressive asymmetric (uneven) paralysis of arms and legs
  • Numbness and tingling or pain in hands and feet
  • Diminished or lack of deep tendon reflexes (areflexia)
  • Inability to sense the orientation of body parts and balance issues (proprioception)
  • Difficulties with balance and proprioception (inability to sense)
  • Decreased response to touch below the knee