Symptoms reported vary between late versus early-onset cases of CMT4JA rare inherited peripheral neuropathy often characterized by rapidly progressive, asymmetrical upper and lower extremity weakness, muscle atrophy leading to handicap, and respiratory issues with no available treatment. CMT4J is a recessive subtype of CMT caused by a variant, also referred to as a mutation, in the FIG4 gene.. Adaptive equipment is typically needed prior to adulthood. Common signs and symptoms during this time include:

• Overwhelming fatigue
• Speech or eating challenges
• Respiratory compromise or muscle weakness leading to respiratory infections
• Rapidly progressive asymmetric (uneven) paralysis of arms and legs
• Numbness and tingling or pain in hands and feet
• Diminished or lack of deep tendon reflexesA tendon is a tough cord or band of dense white fibrosis connective tissue that unites a muscle with another part (for example a bone) and exerts a reflex action in which a muscle is made to contract by a blow upon its tendon. (areflexiaThe absence of reflexes.)
• Inability to sense the orientation of body parts and balance issues (proprioceptionThe perception based on awareness of the position of one’s body.)
• Difficulties with balance and proprioception (inability to sense)
• Decreased response to touch below the knee