Symptoms reported vary between late versus early-onset cases of CMT4J. Adaptive equipment is typically needed prior to adulthood. Common signs and symptoms during this time include:

• Overwhelming fatigue
• Speech or eating challenges
• Respiratory compromise or muscle weakness leading to respiratory infections
• Rapidly progressive asymmetric (uneven) paralysis of arms and legs
• Numbness and tingling or pain in hands and feet
• Diminished or lack of deep tendon reflexesA tendon is a tough cord or band of dense white fibrosis connective tissue that unites a muscle with another part (for example a bone) and exerts a reflex action in which a muscle is made to contract by a blow upon its tendon. (areflexia)
• Inability to sense the orientation of body parts and balance issues (proprioception)
• Difficulties with balance and proprioception (inability to sense)
• Decreased response to touch below the knee